Centrality analysis in a drug network and its application to drug repositioning

Keng, Ying Ying and Kwa, Kiam Heong and Ratnavelu, Kurunathan (2021) Centrality analysis in a drug network and its application to drug repositioning. Applied Mathematics and Computation, 395. ISSN 0096-3003, DOI https://doi.org/10.1016/j.amc.2020.125870.

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Centrality measures play a vital role in network analysis by which important nodes within a network are identified from structural perspectives. In this study, we applied three fundamental centrality measures (degree, closeness, and betweenness) to analyze a drug network where drugs are connected based on their side-effect similarities. The results suggest that centralities of drugs in the network may have a significant implication in drug repositioning - a process of discovering new therapeutic uses of existing drugs. Given a particular disease, the drugs that have been approved for treating it were ranked by their centralities. It is shown that the top central ones among them are more likely to repurpose their neighboring drugs as new treatment options for the disease, as compared to their random and peripheral counterparts. Our predictions have proved to be in line with clinical interests indicated by the existing clinical studies in ClinicalTrials.gov database. The present work offers novel insights into complementing drug repositioning efforts while portraying the significance of network centrality measures in guiding systematic analysis for a successful network application. (c) 2020 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Network analysis; Centrality; Network application; Drug networks; Drug repositioning
Subjects: Q Science > QA Mathematics
Divisions: Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 04 Apr 2022 06:31
Last Modified: 04 Apr 2022 06:31
URI: http://eprints.um.edu.my/id/eprint/27020

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