Current tools for the diagnosis and detection of spotted fever group Rickettsia

Husin, Nurul Aini and AbuBakar, Sazaly and Khoo, Jing Jing (2021) Current tools for the diagnosis and detection of spotted fever group Rickettsia. Acta Tropica, 218. ISSN 0001-706X, DOI

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Spotted fever group (SFG) rickettsiae causes a number of diseases in humans worldwide, which can range from mild to highly lethal. Since the clinical presentations of rickettsioses caused by SFG rickettsiae are variable and may be similar to the diseases caused by other rickettsiae, such as Orientia tsutsugamushi (agent for scrub typhus), Coxiella burnetii (agent for Q fever) and the typhus group rickettsiae (agents for epidemic and murine typhus), the accurate diagnosis of infections caused by SFG Rickettsia remains challenging especially in resource-poor settings in developing countries. This review summarizes the various diagnostic and detection tools that are currently available for the confirmation of infections by SFG rickettsiae. The advantages and challenges pertaining to the different serological and molecular detections methods, as well as new assays in development, are discussed. The utility of the detection tools contributing to the surveillance of SFG rickettsiae in arthropods and animals are reviewed.

Item Type: Article
Funders: Ministry of Education, Malaysia under the Higher Institution Centre of Excellence (HICoE) program [MO0022019], NewtonUngku Omar Fund partnership [332192305], UK Department of Business, Energy and Industrial Strategy (BEIS), Energy and Industrial Strategy and Malaysian IndustryGovernment Group for High Technology (MIGHT), Universiti Malaya, Malaysia [RUU002-2019]
Uncontrolled Keywords: Infectious disease; Tropical; Spotted Fever; Rickettsia; Vector-borne disease; Diagnostic
Subjects: R Medicine
Divisions: Faculty of Medicine
Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre
Depositing User: Ms Zaharah Ramly
Date Deposited: 05 Apr 2022 08:25
Last Modified: 05 Apr 2022 08:25

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