Serum albumin: clinical significance of drug binding and development as drug delivery vehicle

Tayyab, Saad and Feroz, Shevin Rizal (2021) Serum albumin: clinical significance of drug binding and development as drug delivery vehicle. In: Advances In Protein Chemistry and Structural Biology, Vol 123: Transport Proteins. Advances in Protein Chemistry and Structural Biology, 123 . Elsevier Academic Press Inc, 525 B Street, Suite 1900, San Diego, CA 92101-4495 USA, pp. 193-218.

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Human serum albumin, the primary transport and reservoir protein in the human circulatory system, interacts with numerous endogenous and exogenous ligands of varying structural characteristics. The mode of binding of drugs to albumin is central to understanding their pharmacokinetic profiles and has a major influence on their in vivo efficacy. Altered drug binding to albumin due to drug-drug interactions or abnormal physiology may result in marked changes in the active drug concentration, thus affecting its pharmacokinetic and pharmacodynamic properties. The propensity of drug-drug interaction to be clinically significant as well as possible exploitation of such interactions for therapeutic purposes is reviewed. Being the major organs of albumin metabolism, any impairment in the liver and kidney functions frequently alter the level of serum albumin, which affects the pharmacokinetic profiles of drugs and may have serious clinical implications. The natural function of serum albumin as a drug carrier is facilitated by its interaction with various cellular receptors. These receptors not only promote the uptake of drugs into cells but are also responsible for the extraordinarily long circulatory half-life of albumin. This property in combination with the presence of multiple ligand binding pockets have led to the emergence of serum albumin as an attractive vehicle for novel drug delivery systems. Here, we provide an overview of various albumin-based drug delivery strategies, classified according to their methods of drug attachment, and highlight their experimental and clinical successes.

Item Type: Book Section
Uncontrolled Keywords: Serum albumin; Drug binding; Drug delivery vehicle
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 28 Apr 2022 23:53
Last Modified: 28 Apr 2022 23:53

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