A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection

Lim, Yi Wen and Lott, Pooi Wah and Mohamad, Nor Fadhilah and Mohamed Iqbal, Tajunisah Begam (2021) A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection. International Journal of STD and AIDS, 32 (10). pp. 968-973. ISSN 0956-4624, DOI https://doi.org/10.1177/09564624211011917.

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Abstract

Background: Penicillin is the conventional treatment for all stages of syphilis, including ocular and neurosyphilis, according to the recommendations by the Centre for Disease Control and Prevention Sexually Transmitted Disease. This case series highlighted three cases of ocular syphilis which showed prompt treatment response as early as 24 h after the adjunctive intravitreal ceftazidime injection. Methods: Case Series. Results: In case 1, there was significant improvement in the vision and vitritis after 24 h of a single intravitreal ceftazidime injection. In case 2, the patient achieved his best vision after a total of three intravitreal injections in his left eye and one in his right eye. In case 3, there was a further resolution of perivascular sheathing and retinal haemorrhages seen 1 week after a single intravitreal ceftazidime injection. Conclusion: The efficacy of intravitreal ceftazidime injection as a local adjunctive therapy in ocular syphilis treatment is noteworthy. It can be considered in cases which show suboptimal or slower treatment response despite early commencement of systemic penicillin to prevent devastating ocular sequelae.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Ocular syphilis; Uveitis; Neurosyphilis; Intravitreal ceftazidime; Human immunodeficiency virus
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Medicine > Ophthalmplogy Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 15 Apr 2022 04:53
Last Modified: 15 Apr 2022 04:53
URI: http://eprints.um.edu.my/id/eprint/26775

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