Nanotherapeutics for treating coronavirus diseases

Gunathilake, Thennakoon M. Sampath U. and Ching, Yern Chee and Uyama, Hiroshi and Chuah, Cheng Hock (2021) Nanotherapeutics for treating coronavirus diseases. Journal of Drug Delivery Science and Technology, 64. ISSN 1773-2247, DOI

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Viral diseases have recently become a threat to human health and rapidly become a significant cause of mortality with a continually exacerbated unfavorable socio-economic impact. Coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), have threatened human life, with immense accompanying morbidity rates; the COVID-19 (caused by SARS-CoV-2) epidemic has become a severe threat to global public health. In addition, the design process of antiviral medications usually takes years before the treatments can be made readily available. Hence, it is necessary to invest scientifically and financially in a technology platform that can then be quickly repurposed on demand to be adequately positioned for this kind of pandemic situation through lessons learned from the previous pandemics. Nanomaterials/nanoformulations provide such platform technologies, and a proper investigation into their basic science and biological interactions would be of great benefit for potential vaccine and therapeutic development. In this respect, intelligent and advanced nano-based technologies provide specific physico-chemical properties, which can help fix the key issues related to the treatments of viral infections. This review aims to provide an overview of the latest research on the effective use of nanomaterials in the treatment of coronaviruses. Also raised are the problems, perspectives of antiviral nanoformulations, and the possibility of using nanomaterials effectively against current pandemic situations.

Item Type: Article
Funders: AUN/SEED-Net Special Program for Research Against COVID-19 (SPRAC) (IF068-2020)
Uncontrolled Keywords: COVID-19; Nanotechnology; Coronaviruses; Immunization; Virus-like particles; Vaccine; Nanoparticles; Antiviral
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
T Technology > TP Chemical technology
Divisions: Faculty of Engineering > Department of Chemical Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Mar 2022 08:22
Last Modified: 18 Mar 2022 08:23

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