Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection

Khazali, Ahmad Suhail and Rashid, Nurshamimi Nor and Fung, Shin-Yee and Yusof, Rohana (2021) Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection. Journal of Herbal Medicine, 30. ISSN 2210-8033, DOI

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Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02 (R), was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02 (R) cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02 (R) cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of antidengue treatment and limited dengue vaccination, these results indicate that TM02 (R) CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02 (R) CWE that mediate the antiviral activity.

Item Type: Article
Uncontrolled Keywords: Lignosusrhinocerus; Dengue; Antiviral; Virucidal; Prophylaxis
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 Mar 2022 07:28
Last Modified: 09 Mar 2022 07:28

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