Hematocrit change as a predictor of readmission for decompensated heart failure: A retrospective single centre study

Zulastri, Mohd Aizuddin Mohd and Hafidz, Muhammad Imran and Ismail, Muhammad Dzafir and Zuhdi, Ahmad Syadi Mahmood (2021) Hematocrit change as a predictor of readmission for decompensated heart failure: A retrospective single centre study. Reviews in Cardiovascular Medicine, 22 (2). pp. 505-512. ISSN 1530-6550, DOI https://doi.org/10.31083/j.rcm2202058.

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In patients with acute heart failure (AHF), hemoconcentration has been suggested as a surrogate for volume changes (AHF). However, literatures comparing the outcome of AHF patients that achieved hemoconcentration during hospitalization with those that do not are limited. The aim of this research is to see if achieving hemoconcentration prior to discharge is linked to a lower risk of re-admission in AHF patients. 124 patients hospitalized in the Cardiology Unit, University Malaya Medical Centre (UMMC) for AHF between November 2019 and November 2020 were enrolled. Information on patients' clinical characteristics, laboratory values and in-hospital treatments were collected through electronic medical record. At admission and discharge, the change in hematocrit (HCT) levels was calculated, and patients were stratified based on two quantiles of delta HCT, either discharged with hemoconcentration (Delta HCT >1.5%) or without hemoconcentration (Delta HCT <= 1.5%). The study's outcome was AHF readmission after a 90-day follow-up period. Readmission was significantly associated with ejection fraction (p = 0.032) and HCT change (p = 0.005). Consecutively, logistic regression performed revealed that patients with haemoconcentration were 78.3% less likely to be readmitted than those without haemoconcentration (OR = 0.217, p = 0.003, 95% CI = 0.078-0.605) and Patients with a lower ejection fraction have a threefold greater chance of being readmitted than those with a preserved ejection fraction (OR = 3.316, p = 0.022, 95% CI = 1.188-9.256). In conclusion, among patients hospitalized and discharged for AHF, those that (i) do not achieve haemoconcentration and (ii) patients with a reduced ejection fraction were more likely to be readmitted with acute heart failure. Therefore, optimising patients' haematocrit levels prior to discharge may potentially reduce rehospitalizations among heart failure patients.

Item Type: Article
Uncontrolled Keywords: Heart failure; Haemoconcentration; Re-hospitalisations; Outcome; Decompensated
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > School of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 07 Mar 2022 04:56
Last Modified: 07 Mar 2022 04:56
URI: http://eprints.um.edu.my/id/eprint/26469

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