Epidemiology and outcomes of open globe injuries: The international globe and adnexal trauma epidemiology study (IGATES)

Hoskin, Annette K. and Low, Rebecca and Sen, Parveen and Mishra, Chitaranjan and Kamalden, Tengku Ain and Woreta, Fasika and Shah, Mehul and Pauly, Marian and Rousselot, Andres and Sundar, Gangadhara and Natarajan, Sundaram and Keay, Lisa and Gunasekeran, Dinesh Visva and Watson, Stephanie L. and Agrawal, Rupesh and Natarajan, Sundaram and Gooty, Satish and Arjun, - and Pravallika, - and Tarannum, - and Kim, R and Mishra, Chitaranjan and Chaudhary, Meenu and Rousselot, Andres and Shah, Shreya Mehul and Shah, Mehul and Pauly, Marian and Giridhar, - and Khaqan, Hussain and Khatri, Anadi and Jayadev, Chaitra and Jain, Kushagra and Agrawal, Rupesh and Kan, John and Low, Rebecca and Dinesh, VG and Sundar, Gangadhara and Chee, Caroline and Koh, Victor and Khandelwal, Rekha and Sen, Alok and Sen, Parveen and Singh, Shakeen and Awan, Amer and Grover, Ashok and Mittal, Anurag and Hoskin, Annette and Watson, Stephanie and Pradhan, Eli and Kamalden, Tengku Ain and Addenan, Maftuhim and Ch’ng, Hannie and Zamawi, Fatin Nadia and Woreta, Fasika (2021) Epidemiology and outcomes of open globe injuries: The international globe and adnexal trauma epidemiology study (IGATES). Graefe's Archive for Clinical and Experimental Ophthalmology, 259 (11). pp. 3485-3499. ISSN 0721-832X, DOI https://doi.org/10.1007/s00417-021-05266-1.

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Official URL: https://doi.org/10.1007/s00417-021-05266-1


Purpose To detail the methodology for a novel ocular trauma registry and utilize the registry to determine the demographics, nature of injury, and associations of severe visual loss for open globe injuries (OGI). Methods Thirteen hospitals in 7 countries used International Globe and Adnexal Trauma Epidemiology Study (IGATES) platform. Patients presenting between April 2009 and 2020 with OGI (with or without) adnexal involvement or intraocular foreign body (IOFB) were included. Results Analyses of presenting and final VA, using "severe vision loss" (VA <= 6/60) and "no severe loss" (VA > 6/60), were performed. Four hundred fifty-four (64%) patients had VA < 6/60 at presentation and 327 (44.8%) at final follow-up, with a highly significant association between presenting and final VA (p < 0.0001). From the cohort of 746 patients, 37 were missing VA at presentation and 16 at follow-up and complete clinical data was available for 354 patients. The male to female ratio is 6:1, and mean age 36.0 +/- 20.0 years old. Relative afferent pupillary defect (RAPD), zone III injury, IOFB, and eyelid injury at presentation were recorded in 50 (6.7%), 55 (7.8%), 97 (13%), and 87 (11.7%) patients, respectively, and were significantly associated with VA < 6/60 at follow-up. Older age, >= 61 years, was associated with 3.39 times (95% CI: 1.95-5.89) higher risk than <= 20-year-old patients (p < 0.0001) and males 0.424 times (95% CI: 0.27-0.70) lower risk than female (p = 0.0001) of severe vision loss (SVL). Conclusion In OGIs from 13 hospitals, female gender, older age, zone III injury, eyelid injury, and IOFB were associated with higher risk of visual outcome of SVL.

Item Type: Article
Funders: National Health and Medical Research Council of Australia, Appeared in source as: NHMRC PhD Scholarship, Sydney Medical School Foundation
Uncontrolled Keywords: Open globe injury; Ocular trauma; Registry; Prevention; Vision loss
Subjects: R Medicine > R Medicine (General)
R Medicine > RE Ophthalmology
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Feb 2022 07:49
Last Modified: 17 Feb 2022 07:49
URI: http://eprints.um.edu.my/id/eprint/26285

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