Functional roles of neuronal nitric oxide synthase in neurodegenerative diseases and mood disorders

Poon, Chi H. and Tsui, Ka C. and Chau, Sze C. and Chong, Pit S. and Lui, Sylvia W.Y. and Aquili, Luca and Wong, Kah H. and Lim, Lee W. (2021) Functional roles of neuronal nitric oxide synthase in neurodegenerative diseases and mood disorders. Current Alzheimer Research, 18 (10). pp. 831-840. ISSN 15672050, DOI (In Press)

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Nitric oxide synthase (NOS) is well known for its involvement in the regulation of the nervous, cardiovascular, and immune systems. Neuronal NOS (nNOS) is the most characterized NOS among all the isoforms. It accounts for most of the production of nitric oxide (NO) in the nervous system required for synaptic transmission and neuroplasticity. Previous studies have described the localization of nNOS in specific brain regions of interest. There is substantial evidence in the literature suggesting that nNOS signaling has significant involvement in several disease pathologies. However, the association between brain nNOS expression profiles and disease remains largely unknown. In this review, we attempt to delineate the contribution of nNOS signaling in memory and mood disorders in order to achieve a better understanding of nNOS in disease modulation.

Item Type: Article
Funders: General Research Fund of the Hong Kong Research Grants Council, University of Hong Kong (Seed Fund for Basic Research)
Uncontrolled Keywords: Nitric oxide synthase; Alzheimer's disease; Mood disorders; Huntington's disease; Parkinson's disease
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Feb 2022 07:44
Last Modified: 18 Feb 2022 07:44

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