Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection

Khazali, Ahmad Suhail and Nor Rashid, Nurshamimi and Fung, Shin Yee and Yusof, Rohana (2021) Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection. Journal of Herbal Medicine, 30. p. 100505. ISSN 2210-8033, DOI

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Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02®, was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02® cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02® cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of anti-dengue treatment and limited dengue vaccination, these results indicate that TM02® CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02® CWE that mediate the antiviral activity. © 2021 Elsevier GmbH

Item Type: Article
Funders: Ministry of Higher Education of Malaysia [FRGS grant FP007-2017A]
Uncontrolled Keywords: Antiviral; Dengue; Lignosusrhinocerus; Prophylaxis; TM02® Cultivar; Virucidal
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 29 Dec 2021 04:20
Last Modified: 29 Dec 2021 04:20

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