The utility of ALS staging systems in a multi-ethnic patient cohort

Abdul Aziz, Nur Adilah and Toh, Tsun Haw and Loh, Ee Chin and Capelle, David Paul and Goh, Khean Jin and Abdul Latif, Lydia and Chung, Tze Yang and Shahrizaila, Nortina (2021) The utility of ALS staging systems in a multi-ethnic patient cohort. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22 (5-6). pp. 341-349. ISSN 2167-8421, DOI

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Objective: To compare two ALS staging systems, King’s clinical staging and Milano-Torino (MiToS) functional staging, using prospective data from a multi-ethnic cohort of ALS patients. Methods: The stages of disease were determined prospectively based on existing definitions. The two systems were compared for timing of stages using box plots, correspondence using chi-square tests and association using Spearman’s rank correlation. Results: The distribution of stages differed between the two systems. The proportions of disease stages of the King’s staging system were more evenly distributed whereas in MiToS, there was greater weight seen at the later stages of disease. At the early stages, patients moved consecutively in the MiToS staging system but not in the King’s staging system where patients tended to skip stages to reach later stages. Both systems had good correlation (Spearman’s rho = 0.869) and the King’s stage 4 most frequently corresponded to MiToS stage 2. Conclusion: We found the King’s staging was helpful in determining the stages of disease burden, whereas both were helpful in determining the time to functional dependence with MiToS further refining the levels of dependence. © 2021 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.

Item Type: Article
Funders: Malaysian Ministry of Education Fundamental Research Grant Scheme [FRGS/1/2018/SKK08/UM/01/1], ALS Association [IF008-2019], Sydney Southeast Asia Center [IF012-2019]
Uncontrolled Keywords: Amyotrophic lateral sclerosis; Asia; Malaysia; motor neurone disease; multi-ethnic population; staging system
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 21 Sep 2021 04:33
Last Modified: 21 Sep 2021 04:33

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