The study of myocardial ischemia-reperfusion treatment through computational modelling

Wan Ab Naim, Wan Naimah and Mohamed Mokhtarudin, Mohd Jamil and Chan, Bee Ting and Lim, Einly and Ahmad Bakir, Azam and Nik Mohamed, Nik Abdullah (2021) The study of myocardial ischemia-reperfusion treatment through computational modelling. Journal of Theoretical Biology, 509. p. 110527. ISSN 0022-5193, DOI

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Reperfusion of the blood flow to ischemic myocardium is the standard treatment for patients suffering myocardial infarction. However, the reperfusion itself can also induce myocardial injury, in which the actual mechanism and its risk factors remain unclear. This work aims to study the mechanism of ischemia–reperfusion treatment using a three-dimensional (3D) oxygen diffusion model. An electrical model is then coupled to an oxygen model to identify the possible region of myocardial damage. Our findings show that the value of oxygen exceeds its optimum (>1.0) at the ischemic area during early reperfusion period. This complication was exacerbated in a longer ischemic period. While a longer reperfusion time causes a continuous excessive oxygen supply to the ischemic area throughout the reperfusion time. This work also suggests the use of less than 0.8 of initial oxygen concentration in the reperfusion treatment to prevent undesired upsurge at the early reperfusion period and further myocardial injury. We also found the region at risk for myocardial injury is confined in the ischemic vicinity revealed by its electrical conductivity impairment. Although there is a risk that reperfusion leads to myocardial injury for excessive oxygen accumulation, the reperfusion treatment is helpful in reducing the infarct size. © 2020 Elsevier Ltd

Item Type: Article
Funders: Fundamental Research Grant Scheme with code FRGS/1/2017/TK05/UMP/01/1(RDU 170131), Universiti Malaysia Pahang Internal Research Grant (RDU1903121), Universiti Malaysia Pahang (UMP) Post-Doctoral Fellowship in Research
Uncontrolled Keywords: Myocardial infarction; Ischemia; Ischemia-reperfusion; Ischemic injury; Electrophysiology
Subjects: R Medicine
T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 07 May 2021 00:36
Last Modified: 07 May 2021 00:36

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