Intestinal Iron Absorption in Suckling Rats

Loh, Tatt Tuck and Kaldor, I. (2009) Intestinal Iron Absorption in Suckling Rats. Neonatology, 17 (3-4). pp. 173-186. ISSN 1661-7800, DOI

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Using intragastric test doses of 59Fe labelled inorganic iron to measure iron absorption in baby rats the mean percentage absorption exceeded 85 % up to 20 days of age but fell sharply afterwards. Similar results were obtained with milk labelled with 59Fe in vivo or in vitro. Sucklings injected with cortisone acetate during the second week of life absorbed less iron than littermate control animals but hormone injection during the third week of life did not significantly reduce the absorption rate. Sucklings weaned prematurely absorbed less iron than did control animals. Iron dextran injection during either the second or third week of life was also followed by reduced iron absorption as was hypertransfusion with red blood cells. The in vivo uptake of radio-iron from a test dose was greatest in the upper duodenal and lowest in the lower ileal gut segments with a gradient in segments in between and this pattern was identical at 15 and 25 days of age. © 1971 S. Karger AG, Basel.

Item Type: Article
Uncontrolled Keywords: Animal; Animals, Newborn; Blood Transfusion; Body Weight; Cortisone; Duodenum; Ileum; Intestinal Absorption; Intestine, Small; Iron; Iron Isotopes; Jejunum; Milk; Rats; Reticulocytes; Stomach
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Mar 2021 04:38
Last Modified: 30 Mar 2021 04:38

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