Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients

Yugavathy, Nava and Huri, Hasniza Zaman and Lim, Soo Kun and Abdul Gafor, Abdul Halim and Wong, Muh Geot and Bavanandan, Sunita and Wong, Hing Seng (2020) Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients. Biomarkers in Medicine, 14 (12). pp. 1099-1108. ISSN 1752-0363, DOI

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Aim: To determine the clinical and genetic markers associated with erythropoietin deficiency anemia in predialysis individuals. Materials & methods: Patients were categorized into cases and control group. Demographic characteristics and clinical parameters were obtained from medical record review and serum EPO and ferritin were obtained with ELISA. HIF-1α (rs2057482), IL-1β (rs1143627) and EPO (rs1617640) gene polymorphism were genotyped. Results: Female gender, glomerular filtration rate, treatment with hematinics, anticoagulant and diuretic were strong predictors of EPO-deficient anemia in predialysis chronic kidney disease patients. Genetic polymorphism in the HIF-1α recessive model was associated with non-EPO-deficiency, followed by EPO recessive allele associated with low-serum erythropoietin and IL-1β recessive model with low hemoglobin level. Conclusion: EPO-deficiency anemia can be diagnosed more conveniently in the presence of biomarkers. © 2020

Item Type: Article
Funders: Fundamental Research Grant Scheme (FRGS) FP020-2016
Uncontrolled Keywords: EPO deficiency; EPO gene; genetic polymorphism; HIF-1α; IL-1β; predialysis; renal anemia
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 Feb 2021 07:48
Last Modified: 09 Feb 2021 07:48

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