Cytotoxic Activity of Pereskia bleo (Cactaceae) Against Selected Human Cell Lines

Malek, Sri Nurestri Abd and Wahab, Norhanom Abdul and Yaacob, Hashim and Sim, Kae Shin and Lai, Hong Sok and Lee, Guan Serm and Syed Abdul Rahman, Syarifah Nur (2007) Cytotoxic Activity of Pereskia bleo (Cactaceae) Against Selected Human Cell Lines. International Journal of Cancer Research, 4 (1). pp. 20-27. ISSN 1811-9727, DOI

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Pereskia bleo (Cactaceae) was investigated for its cytotoxic effect against selected human cell lines, namely the Human Nasopharyngeal Fpidermoid Carcinoma Cell Line (KB), Human Cervical Carcinoma Cell Line (CasKi), Human Colon Carcinoma Cell Line (HCT 116), Hormone-Dependent Breast Carcinoma Cell Line (MCF7) and non-cancer Human Fibroblast Cell Line (MRC-5) by using an in vitro neutral red cytotoxicity assay. All the crude methanolic and its fractionated extracts (hexane, ethyl acetate and water) exert no damage to the MRC-5 normal cells. The crude methanol extract and the ethyl acetate fraction of Pereskia bleo possessed notably high cytotoxic effect against KB cells with IC50 values of 6.5 and 4.5 μg mL-1, respectively. Four compounds isolated from the ethyl acetate fraction of Pereskia bleo were identified as phytol, β-sitosterol, 2,4-di-tert-butylphenol and vitamin E. All four compounds have not been reported for this plant. © 2008 Academic Journals Inc.

Item Type: Article
Uncontrolled Keywords: Cytotoxic activity; Pereskia bleo
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Dec 2020 04:07
Last Modified: 17 Dec 2020 04:07

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