Multiple sclerosis in South East Asia and diagnostic criteria for Asians

Chong, Heng Thay (2008) Multiple sclerosis in South East Asia and diagnostic criteria for Asians. Neurology Asia, 13 (2). pp. 145-146. ISSN 1823-6138,

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Multiple sclerosis is an uncommon disease in Southeast Asia, having been characterised only recently. The estimated prevalence is about 2 - 3/ 105, with high female to male ratio, but rare family history. As high as 40% of the patients had the optic-spinal phenotype; though patients in this region seldom progressed to the secondary progressive phase, disability was more severe due to severe spinal cord involvement. There is a great degree of overlap in clinical, radiological and laboratory features between the classical and the optic-spinal phenotypes, including long spinal cord involvement, few brain lesions, lower proportion of positive cerebrospinal fluid oligoclonal bands and anti-aquaporin-4 antibody. We proposed that future international diagnostic criteria need to take this into account.

Item Type: Article
Uncontrolled Keywords: Myelooptic Neuropathy; Myelin Oligodendrocyte Glycoprotein; Aquaporin 4
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 10 Dec 2020 02:39
Last Modified: 10 Dec 2020 02:39

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