Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome

Abdel-Latif, Mohamed El-Amin and Chan, Patrick Wai Kiong and Goh, Adrian Yu Teik and Lum, Lucy Chai See (2009) Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome. Case Reports, 2009 (feb19). bcr0620080135-bcr0620080135. ISSN 1757-790X, DOI https://doi.org/10.1136/bcr.06.2008.0135.

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Official URL: https://doi.org/10.1136/bcr.06.2008.0135


We describe cerebral salt wasting syndrome (CSWS) in a 5-year-old female child with Down syndrome who had acute myelopathy secondary to chronic atlantoaxial subluxation and fracture dislocation of the odontoid process. The patient developed hyponatraemia associated with excessive urine output and elevated urine sodium concentration following her injury. An administered volume-for-volume replacement of urine loss with 0.9% sodium chloride resulted in an excellent outcome. This patient illustrates the importance of ascertaining CSWS in children with spinal cord disorders, in addition to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and diabetes insipidus (DI) commonly encountered following a central nervous system (CNS) injury, as the specific treatment approaches is clearly associated with an excellent outcome.

Item Type: Article
Uncontrolled Keywords: Hyponatremia; Wasting Syndrome; Inappropriate Vasopressin Secretion
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Oct 2020 03:27
Last Modified: 16 Oct 2020 03:27
URI: http://eprints.um.edu.my/id/eprint/25568

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