Synthesis, cytotoxicity and antimalarial activities of thiosemicarbazones and their nickel (II) complexes

Savir, Savina and Wei, Zi Jun and Liew, Jonathan Wee Kent and Vythilingam, Indra and Lim, Yvonne Ai Lian and Saad, Hazwani Mat and Sim, Kae Shin and Tan, Kong Wai (2020) Synthesis, cytotoxicity and antimalarial activities of thiosemicarbazones and their nickel (II) complexes. Journal of Molecular Structure, 1211. p. 128090. ISSN 0022-2860, DOI

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A series of Schiff base metal complexes with the formulations [Ni(L1)2] (4), [Ni(L2)2] (5) and [Ni(L3)2] (6), (where 1 or L1 = fluorene-2-carboxaldehyde thiosemicarbazone, 2 or L2 = fluorene-2-carboxaldehyde-4-methyl-thiosemicarbazone and 3 or L3 = fluorene-2-carboxaldehyde-4-ethyl-thiosemicarbazone) have been synthesised. The compounds were characterised by FT-IR, 1H NMR, 13C NMR, and single crystal X-Ray diffraction. The results suggested that the thiosemicarbazone ligands behaved as bidentate ligands which were coordinated to the Ni(II) ion via their N,S atoms. Among the six compounds tested, two of the nickel complexes which are complexes 5 and 6 exhibited moderate in vitro antimalarial activity with IC50 of 23.79 and 2.29 μM, respectively. It is noteworthy that as the size of the substituent group increases, the antimalarial activity of the compound increases. Complex 6 exhibited the highest antimalarial activity. In addition, ligand 3 and complex 4 showed higher cytotoxic activity against HCT 116 human colorectal carcinoma cell line than cisplatin with IC50 of 0.69 and 3.36 μM, respectively. © 2020 Elsevier B.V.

Item Type: Article
Funders: University of Malaya Research Grant (grant number RP033A-17AFR), MOHE ( FRGS-FP006-2015A ), MyBrain Scholarship
Uncontrolled Keywords: Schiff base; Thiosemicarbazone; Metal complex; Anticancer activity; Antimalarial activity
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history
R Medicine
Divisions: Faculty of Medicine
Faculty of Science > Department of Chemistry
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Jul 2020 03:06
Last Modified: 17 Jul 2020 03:06

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