Chemicals Constituents Isolated from Cultivate Alpinia conchigera Griff. and Antimicrobial Activity

Mohamad Taib, Mohamad Nurul Azmi and Anuar, Nursyazwani and Mohd Hanafiah, Khayriyyah and Al-Shammary, Aeman Ali Kudayr and Saaid, Mardiana and Awang, Khalijah (2020) Chemicals Constituents Isolated from Cultivate Alpinia conchigera Griff. and Antimicrobial Activity. Tropical Life Sciences Research, 31 (1). pp. 159-178. ISSN 1985-3718, DOI

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Alpinia conchigera Griff. is a plant species from the family Zingiberaceae. Coloquially known as wild ginger, Alpinia conchigera Griff. is used as food condiment and for traditional treatment of skin diseases. Isolation studies to identify bioactive compounds of rhizomes of Alpinia conchigera yielded seven compounds; 1‘S-1'-acetoxychavicol acetate (1), trans-p-coumaryl diacetate (2), p-hydroxycinnamyl acetate (3), 1‘S-1'-hydroxychavicol acetate (4) p-hydroxybenzaldehyde (5), stigmasterol (6) and β-sitosterol (7). Compounds 1, 2 and 5 were evaluated for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). Among the compounds tested, Compound 1 showed good antimicrobial activity against the strain of MRSA with minimum inhibition concentration (MIC) value of 0.5 mg/mL. Meanwhile, Compounds 2 and 5 exhibited moderate activity with MIC value between 1.0 and 2.0 mg/mL. These findings indicate antimicrobial potential of 1‘S-1'- acetoxychavicol acetate (1), compound derived from rhizome of Alpinia conchigera Griff. against MRSA, which warrant further investigation. © Penerbit Universiti Sains Malaysia, 2020.

Item Type: Article
Funders: Universiti Sains Malaysia, Pulau Pinang for providing grant 304/PKIMIA/6313330
Uncontrolled Keywords: Alpinia conchigera griff.; Antimicrobial; Methicilin resistant staphlococcus aureus; MRSA; Zingiberaceae
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Jun 2020 02:24
Last Modified: 16 Jun 2020 02:24

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