Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata

Chung, L.Y. and Yap, K.F. and Mustafa, Mohd Rais and Goh, S.H. and Imiyabir, Z. (2008) Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata. Phytochemistry, 69 (7). pp. 1548-1554. ISSN 0031-9422, DOI

[img] PDF
Muscarinic_receptor_binding_activity_of_polyoxygenated_flavones_from_Melicope_subunifoliolata.pdf - Published Version
Restricted to Registered users only

Download (173kB) | Request a copy


The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata. Themethoxyflavones (compounds 1, 3, 4, 5, 6, and 7) show moderate inhibition in a muscarinic receptor binding assay, while the furanocoumarin (compound 2) is inactive. The potency of the methoxyflavones to inhibit [ 3 H]NMS-muscarinic receptor binding is influenced by the position and number of methoxy substitution. The results suggest these compounds are probably muscarinic modulators, agonists or partial agonists/antagonists.

Item Type: Article
Additional Information: Corresponding author. Tel.: +603 79674909; fax: +603 79674964. E-mail addresses:,
Uncontrolled Keywords: Melicope Subunifoliolata; Rutaceae; Flavonoid; Muscarinic Receptor
Subjects: Q Science > QD Chemistry
R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 17 Jan 2012 03:41
Last Modified: 18 Dec 2019 06:25

Actions (login required)

View Item View Item