Expression of human b-defensin-3 in oral squamous cell carcinoma using tissue microarray - A preliminary study

Hussaini, H.M. and Lim, P.K. and Rahman, R.A. and Abraham, T. and Cheong, C.S. and Zain, R.B. and Ismail, M.S. and Nam, A.N. (2006) Expression of human b-defensin-3 in oral squamous cell carcinoma using tissue microarray - A preliminary study. Journal of Oral Pathology and Medicine, 35 (7). pp. 432-433. ISSN 0904-2512,


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Purpose: Human b-Defensin (hBDs) is an epithelial origin, cationic antimicrobial peptides. Their expression is reported in oral mucosa, gingiva and salivary glands. However, their protective role is not well understood. It has been suggested that bacterial and viral infection are an important factors in the process of carcinogenesis. This study investigated the expression of hBD-3 in oral squamous cells carcinoma (OSCC). Methods: 29 OSCC and 23 samples of normal and dysplastic tissues were obtained from Oral Pathology diagnostic laboratory, faculty of Dentistry, UKM and UM. The tissues were arrayed and the expression of hBD-3 was analysed using immunohistochemistry technique. Results: Higher levels of hBD-3 expression were found in stage II and II of OSCC compared to stage I and IV. Expression of hBD-3 was also seen higher in the tumour front arrays. Healthy and dysplastic tissues also seen to expressed hBD-3 but most are moderately stained. Conclusion: High levels of hBD-3 expression is seen especially in stage II and III as well as in tumour front suggest a potential tumour marker, correlation between level of expression and probable infective cancer causes need to be investigate further.

Item Type: Article
Additional Information: Prof. Dr. Rosnah Mohd Zain Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya
Uncontrolled Keywords: Oral Squamous Cell Carcinoma, OSCC, Lichenoid Lesions, Lichen Planus, Oral Cancer, Oral Tumours, Pemphigus, Traumatic Eosinophilic Granuloma, Aphthous Ulcers, Oral Mucosal Lesions, Betel Chewers Mucosa, Betel Quid Related Lesions, Betel Quid, Areca Quid, Tobacco Quid, Oral Cancer Screening, Training and Calibration, Early Detection, Oral Cancer Awareness, Biobanking, Tissue Bank, Databank, Oral Cancer, Tissue Bank, Research Credibility, Research Ethics.
Subjects: R Medicine
R Medicine > RK Dentistry
R Medicine > RK Dentistry > Oral surger
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Prof. Dr. Rosnah Mohd Zain
Date Deposited: 17 Jan 2012 01:21
Last Modified: 08 Jul 2017 07:19

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