Boron Nitride Doped Polyhydroxyalkanoate/Chitosan Nanocomposite for Antibacterial and Biological Applications

Mukheem, Abdul and Shahabuddin, Syed and Akbar, Noor and Miskon, Azizi and Sarih, Norazilawati Muhamad and Sudesh, Kumar and Ahmed Khan, Naveed and Saidur, Rahman and Sridewi, Nanthini (2019) Boron Nitride Doped Polyhydroxyalkanoate/Chitosan Nanocomposite for Antibacterial and Biological Applications. Nanomaterials, 9 (4). p. 645. ISSN 2079-4991, DOI

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The present research focused on the fabrication of biocompatible polyhydroxyalkanoate, chitosan, and hexagonal boron nitride incorporated (PHA/Ch-hBN) nanocomposites through a simple solvent casting technique. The fabricated nanocomposites were comprehensively characterized by Fourier transform infrared spectroscope (FT-IR), field emission scanning electroscope (FESEM), and elemental mapping and thermogravimetric analysis (TGA). The antibacterial activity of nanocomposites were investigated through time-kill method against multi drug resistant (MDR) microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) K1 strains. In addition, nanocomposites have examined for their host cytotoxicity abilities using a Lactate dehydrogenase (LDH) assay against spontaneously immortalized human keratinocytes (HaCaT) cell lines. The results demonstrated highly significant antibacterial activity against MDR organisms and also significant cell viability as compared to the positive control. The fabricated PHA/Ch-hBN nanocomposite demonstrated effective antimicrobial and biocompatibility properties that would feasibly suit antibacterial and biomedical applications. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Funders: Ministry of Energy, Science, Technology, Environment and Climate Change (MESTECC), Malaysia through the Science Fund grant (No. 2014/03-01-19-SF0127), Sunway University through internal grant (INT-2019-SST-RCNMET-02)
Uncontrolled Keywords: boron nitride; chitosan; polyhydroxyalkanoate; nanocomposite; biocompatible; antibacterial
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 04 Mar 2020 00:45
Last Modified: 04 Mar 2020 00:45

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