Sahimin, Norhidayu and Sharif, Siti Aishah and Mohd Hanapi, Izzah Ruzana and Nai Chuan, Sukchinda and Lewis, John Watkin and Douadi, Benacer and Mohd Zain, Siti Nursheena (2019) Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia. The American Journal of Tropical Medicine and Hygiene, 101 (6). pp. 1265-1271. ISSN 0002-9637, DOI https://doi.org/10.4269/ajtmh.19-0003.
Full text not available from this repository.Abstract
Leptospirosis is a zoonotic bacterial disease caused by pathogenic species of the genus Leptospira. Disease incidenceisknowntobeattributed toenvironmental and social conditions which promote the spread ofreservoir hosts, primarily rodents. A well-being program was conducted to determine the seroprevalence and risk factors associated with leptospirosis inurban poor communities occupying low-cost flat accommodation and squatter settlements in the vicinity of Wilayah Persekutuan, Kuala Lumpur. Blood samples from a total of 532 volunteers were screened for the detection of IgG and IgM antibodies against leptospirosis using ELISA. Demographic data were collected for each participant through a questionnaire survey before blood collection. The overall seroprevalence was low (12.6%, n = 67/532; 95% CI: 9.9-15.7%), with 8.1% (n=43/532) being seropositive for anti-Leptospira Ig G, indicating previous infection, and 4.9% (n = 26/532) for anti-Leptospira Ig M, indicating current infection. Two significant factors such as host age (P ≤ 0.01) and knowledge of disease transmission (P = 0.017) significantly influenced the presence of anti-Leptospira Ig M, whereas the detection of anti-IgG indicated the presence of clean drinking water sources (P = 0.043). Despite the low prevalence, the transmission of leptospirosis does occur among urban poor communities, suggesting the need for undertaking public awareness programs. Copyright © 2019 by The American Society of Tropical Medicine and Hygiene.
| Item Type: | Article |
|---|---|
| Funders: | AJ Biologics Sdn Bhd. (PV006-2017), Geran Penyelidikan Fakulti, University of Malaya (GPF012B-2018) |
| Uncontrolled Keywords: | Leptospirosis; Leptospira; Canine leptospirosis |
| Subjects: | Q Science > QR Microbiology R Medicine |
| Divisions: | Faculty of Science > Institute of Biological Sciences Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Jan 2020 01:34 |
| Last Modified: | 28 Jan 2020 01:34 |
| URI: | http://eprints.um.edu.my/id/eprint/23590 |
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