Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population

Sun, Yan and Chen, Gang and Wang, Li and Li, Nan and Srisurapanont, Manit and Hong, Jin Pyo and Sulaiman, Ahmad Hatim and Chen, Chia-hui and Udomratn, Pichet and Bae, Jae Nam and Fang, Yi-Ru and Chua, Hong Choon and Liu, Shen-Ing and George, Tom and Bautista, Dianne and Chan, Edwin and Rush, A. John and Yang, Hong and Su, Yun-Ai and Si, Tian-Mei (2019) Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population. Frontiers in Psychiatry, 10. p. 321. ISSN 1664-0640, DOI

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Stigma of major depressive disorder (MDD) is an important public health problem. This study aimed to examine the level of perceived stigma and its associated factors in MDD patients in five Asian countries, including China, Korea, Malaysia, Singapore, and Thailand. A total of 547 outpatients with MDD were included from Asian countries. We used the stigma scale of the Explanatory Model Interview Catalogue (EMIC) to assess stigma. The Montgomery-Asberg Depression Rating Scale (MADRS), Symptoms Checklist 90-Revised (SCL-90-R), Fatigue Severity Scale (FSS), Sheehan Disability Scale (SDS), 36-Item Short-Form Health Survey (SF-36), and Multidimensional Scale of Perceived Social Support (MSPSS) were used to assess symptoms, clinical features, functional impairment, health status, and social support. The stigma scores of patients under 55 years old were significantly higher than those equal to or greater than 55 years old (P < 0.001). The stigma scores exhibited significant negative correlation with age; MSPSS scores of family, friends, and others; and SF-36 subscale of mental health, but significant positive correlation with MADRS, FSS, SDS, and SCL-90-R subscale scores of depression, interpersonal sensitivity, obsession-compulsion, psychoticism, and somatization. Multivariate regression analysis revealed that age, SCL-90-R interpersonal sensitivity, obsession-compulsion, psychoticism, MSPSS scores of friends and others, and SF-36 of mental health were significantly associated with the level of perceived stigma. These findings suggest that MDD patients who are young, have a high degree of interpersonal sensitivity and psychoticism, have low health-related quality of life, and have low social support are the target population for stigma interventions in Asia. © 2019 Sun, Chen, Wang, Li, Srisurapanont, Hong, Hatim, Chen, Udomratn, Bae, Fang, Chua, Liu, George, Bautista, Chan, Rush, Yang, Su and Si. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Item Type: Article
Funders: National Natural Science Foundation of China (No. 81630031), Capital Medical Development Research Fund (2016-1-4111), Beijing Municipal Science and Technology
Uncontrolled Keywords: Asia; Associated factors; Major depressive disorder; Social support; Stigma
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 Jan 2020 02:30
Last Modified: 09 Jan 2020 02:30

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