Mangrove derived Streptomyces sp. MUM265 as a potential source of antioxidant and anticolon-cancer agents

Tan, Loh Teng Hern and Chan, Kok Gan and Pusparajah, Priyia and Yin, Wai Fong and Khan, Tahir Mehmood and Lee, Learn Han and Goh, Bey Hing (2019) Mangrove derived Streptomyces sp. MUM265 as a potential source of antioxidant and anticolon-cancer agents. BMC Microbiology, 19 (1). p. 38. ISSN 1471-2180, DOI

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Background: Colon cancer is the third most commonly diagnosed cancer worldwide, with a commensurately high mortality rate. The search for novel antioxidants and specific anticancer agents which may inhibit, delay or reverse the development of colon cancer is thus an area of great interest; Streptomyces bacteria have been demonstrated to be a source of such agents. Results: The extract from Streptomyces sp. MUM265 - a strain which was isolated and identified from Kuala Selangor mangrove forest, Selangor, Malaysia - was analyzed and found to exhibit antioxidant properties as demonstrated via metal-chelating ability as well as superoxide anion, DPPH and ABTS radical scavenging activities. This study also showed that MUM265 extract demonstrated cytotoxicity against colon cancer cells as evidenced by the reduced cell viability of Caco-2 cell line. Treatment with MUM265 extract induced depolarization of mitochondrial membrane potential and accumulation of subG 1 cells in cell cycle analysis, suggesting that MUM265 exerted apoptosis-inducing effects on Caco-2 cells. Conclusion: These findings indicate that mangrove derived Streptomyces sp. MUM265 represents a valuable bioresource of bioactive compounds for the future development of chemopreventive agents, with particular promise suggested for treatment of colon cancer. © 2019 The Author(s).

Item Type: Article
Funders: PVC Award Grant (Project No. PVC-ECR-2016), External Industry Grant (Biotek Abadi – Vote No. GBA-808813), Fundamental Research Grant Scheme (FRGS/1/2013/SKK01/MUSM/03/3), MOSTI eScience funds (Project No. 06-02-10-SF0300), External Industry Grant (Biotek Abadi – Vote No. GBA-81811A), MOSTI eScience funds (Project No. 02-02-10-SF0215), University of Malaya Research Grants (PPP grants PG088-2015B and PG089-2015B and JBK grant GA002-2016)
Uncontrolled Keywords: Antioxidant; Colon cancer; Cytotoxic; Mangroves; Streptomyces
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QR Microbiology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 03 Jan 2020 05:47
Last Modified: 03 Jan 2020 05:47

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