Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization

Thavoncharoensub, Ninticha and Maruyama, Kento and Heh, Choon Han and Leong, Kok Hoong and Shi, Hui and Shigematsu, Yoshiharu and Sasaki, Shigeki and Taniguchi, Yosuke (2019) Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization. Nucleosides, Nucleotides and Nucleic Acids, 38 (8). pp. 578-589. ISSN 1525-7770, DOI

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8-OxodGTP is generated by the reaction between dGTP and reactive oxygen species and a considered mutagenic nucleotide. It can be incorporated into the duplex DNA during replication processes by the DNA polymerase, and thus the repair enzyme removes oxodGTP from the nucleotide pools in living cells. On the other hand, the γ-modified triphosphates show interesting properties for use as biological tools. Therefore, the γ-N-pyrenylalkyl-oxodGTP derivatives were synthesized and their effect on the enzymatic reactions were evaluated. The γ-N-pyrenylmethyl-oxodGTP was found to be accepted by the DNA polymerase just like oxodGTP, but showed a competitive inhibition property for the human oxodGTPase. © 2019, © 2019 Taylor & Francis Group, LLC.

Item Type: Article
Funders: Grant-in-Aid for Scientific Research (B) [JSPS KAKENHI Grant Number 16H05100], Takeda Science Foundation, Fukuoka Foundation for Sound Health Cancer Research Fund
Uncontrolled Keywords: 8-oxodGTP; gamma phosphate modification; DNA polymerase; repair enzyme
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Dec 2019 02:09
Last Modified: 18 Dec 2019 02:09

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