Genomic analyses of two Alteromonas stellipolaris strains reveal traits with potential biotechnological applications

Torres, Marta and Hong, Kar Wai and Chong, Teik Min and Reina, José Carlos and Chan, Kok Gan and Dessaux, Yves and Llamas, Inmaculada (2019) Genomic analyses of two Alteromonas stellipolaris strains reveal traits with potential biotechnological applications. Scientific Reports, 9 (1). p. 1215. ISSN 2045-2322, DOI

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The Alteromonas stellipolaris strains PQQ-42 and PQQ-44, previously isolated from a fish hatchery, have been selected on the basis of their strong quorum quenching (QQ) activity, as well as their ability to reduce Vibrio-induced mortality on the coral Oculina patagonica. In this study, the genome sequences of both strains were determined and analyzed in order to identify the mechanism responsible for QQ activity. Both PQQ-42 and PQQ-44 were found to degrade a wide range of N-acylhomoserine lactone (AHL) QS signals, possibly due to the presence of an aac gene which encodes an AHL amidohydrolase. In addition, the different colony morphologies exhibited by the strains could be related to the differences observed in genes encoding cell wall biosynthesis and exopolysaccharide (EPS) production. The PQQ-42 strain produces more EPS (0.36 g l−1) than the PQQ-44 strain (0.15 g l−1), whose chemical compositions also differ. Remarkably, PQQ-44 EPS contains large amounts of fucose, a sugar used in high-value biotechnological applications. Furthermore, the genome of strain PQQ-42 contained a large non-ribosomal peptide synthase (NRPS) cluster with a previously unknown genetic structure. The synthesis of enzymes and other bioactive compounds were also identified, indicating that PQQ-42 and PQQ-44 could have biotechnological applications. © 2019, The Author(s).

Item Type: Article
Funders: Spanish Ministry of Economy, Industry and Competitiveness research project (AGL2015-68806-R), French National Scientific Research Center (CNRS), French Embassy in Malaysia, University of Malaya (grants H-50001-A000027 and GA001-2016), LabEx Saclay Plant Sciences-SPS (ANR-10-LABX-0040-SPS), FPU Fellowship (FPU13-0466), International Mobility Programme (EST15/00709) of the Spanish Ministry of Science and Education, FPU Fellowship grant (FPU15-01717)
Uncontrolled Keywords: Quorum Sensing; Biofilms; Homoserine lactones
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QR Microbiology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Dec 2019 00:55
Last Modified: 17 Dec 2019 00:55

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