Macroline–Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana

Yeap, Joanne Soon Yee and Saad, Hazwani Mat and Tan, Chun Hoe and Sim, Kae Shin and Lim, Siew Huah and Low, Yun Yee and Kam, Toh Seok (2019) Macroline–Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana. Journal of Natural Products, 82 (11). pp. 3121-3132. ISSN 0163-3864, DOI

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A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, 7). Analysis of the spectroscopic data (NMR and MS) of these compounds led to the proposed structures of these alkaloids. The macroline-sarpagine alkaloids (1-6) showed in vitro growth inhibitory activity against a panel of human cancer cell lines, inclusive of KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, HCT 116, and A549 cells (IC50 values: 0.02-9.0 μM). Copyright © 2019 American Chemical Society and American Society of Pharmacognosy.

Item Type: Article
Funders: University of Malaya (UMRG, RP036-17AFR)
Uncontrolled Keywords: Alstonia; Alkaloids; Monoterpenoid indole
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history
Divisions: Faculty of Science > Department of Chemistry
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Nov 2019 04:08
Last Modified: 27 Nov 2019 04:08

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