Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives

Zonouzi, Afsaneh and Hosseinzadeh, Fatemeh and Karimi, Nastaran and Mirzazadeh, Roghieh and Ng, Seik Weng (2013) Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives. ACS Combinatorial Science, 15 (5). pp. 240-246. ISSN 2156-8952, DOI

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A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno[2,3-d]-pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H- bonding of two of the new compounds are reported by X-ray analysis data. © 2013 American Chemical Society.

Item Type: Article
Uncontrolled Keywords: chromenopyrimidine; fluorescent; green procedure; intramolecular H-bonding; Lewis acid; one-pot reaction
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Nov 2019 08:56
Last Modified: 19 Nov 2019 08:56

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