Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

Wan Othman, Wan Nurul Nazneem and Sivasothy, Yasodha and Liew, Sook Yee and Mohamad, Jamaludin and Nafiah, Mohd Azlan and Ahmad, Kartini and Litaudon, Marc and Awang, Khalijah (2017) Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity. Phytochemistry Letters, 21. pp. 230-236. ISSN 1874-3900, DOI

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(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.

Item Type: Article
Funders: University of Malaya: the University Research Grants (PPP: PV049/2012A) and (UMRP: RP001-2012A/B)
Uncontrolled Keywords: Cryptocarya densiflora Blume; (−)-Desmethylsecoantofine N-oxide; Prodensiflorin A; Prodensiflorin B; Cholinesterase inhibitory activities; DPPH free radical scavenging activity
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history
Divisions: Faculty of Science > Department of Chemistry
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Oct 2019 04:00
Last Modified: 24 Oct 2019 04:00

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