Microstructural integrity of white matter tracts amongst older fallers: A DTI study

Forloni, Gianluigi and Wong, Yoke Queen and Tan, Li Kuo and Seow, Pohchoo and Tan, Maw Pin and Abd Kadir, Khairul Azmi and Vijayananthan, Anushya and Ramli, Norlisah (2017) Microstructural integrity of white matter tracts amongst older fallers: A DTI study. PLoS ONE, 12 (6). e0179895. ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0179895.

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Official URL: https://doi.org/10.1371/journal.pone.0179895


Objectives: This study assesses the whole brain microstructural integrity of white matter tracts (WMT) among older individuals with a history of falls compared to non-fallers. Methods: 85 participants (43 fallers, 42 non-fallers) were evaluated with conventional MRI and diffusion tensor imaging (DTI) sequences of the brain. DTI metrics were obtained from selected WMT using tract-based spatial statistics (TBSS) method. This was followed by binary logistic regression to investigate the clinical variables that could act as confounding elements on the outcomes. The TBSS analysis was then repeated, but this time including all significant predictor variables from the regression analysis as TBSS covariates. Results: The mean diffusivity (MD) and axial diffusivity (AD) and to a lesser extent radial diffusivity (RD) values of the projection fibers and commissural bundles were significantly different in fallers (p < 0.05) compared to non-fallers. However, the final logistic regression model obtained showed that only functional reach, white matter lesion volume, hypertension and orthostatic hypotension demonstrated statistical significant differences between fallers and non-fallers. No significant differences were found in the DTI metrics when taking into account age and the four variables as covariates in the repeated analysis. Conclusion: This DTI study of 85 subjects, do not support DTI metrics as a singular factor that contributes independently to the fall outcomes. Other clinical and imaging factors have to be taken into account.

Item Type: Article
Uncontrolled Keywords: Accidental Falls; Aged; Aged, 80 and over; Case-Control Studies; Diffusion Tensor Imaging; Female; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Risk Factors; White Matter
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 21 Oct 2019 07:38
Last Modified: 21 Oct 2019 07:38
URI: http://eprints.um.edu.my/id/eprint/22780

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