AFM analysis of collagen fibrils in expanded scalp tissue after anisotropic tissue expansion

Aziz, Jazli and Ahmad, Muhamad Fadhil and Rahman, Mohammad Tariqur and Yahya, Noor Azlin and Czernuszka, Jan and Radzi, Zamri (2018) AFM analysis of collagen fibrils in expanded scalp tissue after anisotropic tissue expansion. International Journal of Biological Macromolecules, 107. pp. 1030-1038. ISSN 0141-8130, DOI

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Successful use of tissue expanders depends on the quality of expanded tissue. This study evaluates the impact of anisotropic self-inflating tissue expander (SITE) on the biomechanics of skin. Two different SITE were implanted subcutaneously on sheep scalps; SITE that requires 30 days for maximum expansion (Group A; n = 5), and SITE that requires 21 days for maximum expansion (Group B; n = 5). Control animals (n = 5) were maintained without SITE implantation. Young's Modulus, D-periodicity, overlap and gap region length, diameter, and height difference between overlap and gap regions on collagen fibrils were analyzed using atomic force microscopy. Histology showed no significant differences in dermal thickness between control and expanded skin of groups A and B. Furthermore, most parameters of expanded skin were similar to controls (p > 0.05). However, the height difference between overlap and gap regions was significantly smaller in group B compared to both control and group A (p < 0.01). Strong correlation was observed between Young's Modulus of overlap and gap regions of the control and group A, but not group B. Results suggest that a relatively slower SITE can be useful in reconstructive surgery to maintain the biomechanical properties of expanded skin.

Item Type: Article
Funders: High Impact Research MoE Grant UM.C/625/1/HIR/MoE/Dent21 from the Ministry of Education Malaysia, Research grant BKS006-2016 from the Centre for Research Grant Management, Research Management & Innovation Complex, University of Malaya
Uncontrolled Keywords: self-inflating tissue expanders; Young’s modulus; D-periodicity; Skin; Mechanical properties
Subjects: Q Science > QH Natural history
R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Sep 2019 03:23
Last Modified: 18 Sep 2019 03:23

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