Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts

Chan, Bee Ting and Yeoh, Hak Koon and Liew, Yih Miin and Dokos, Socrates and Al Abed, Amr and Chee, Kok Han and Abdul Aziz, Yang Faridah and Sridhar, Ganiga Srinivasaiah and Chinna, Karuthan and Lim, Einly (2018) Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts. Coronary Artery Disease, 29 (4). pp. 316-324. ISSN 0954-6928, DOI https://doi.org/10.1097/MCA.0000000000000596.

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Official URL: https://doi.org/10.1097/MCA.0000000000000596


Objective This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. Patients and methods Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI. Results The results obtained showed no significant differences in intraventricular flow variables between the healthy group and the patients with normal ejection fraction group, whereas considerable reductions in kinetic energy (KE) fluctuation index, E′ (P<0.001) and vortex KE (P=0.003) were found in the patients with reduced ejection fraction group. In multivariate analysis, only vortex KE and infarct size were significantly related to LV ejection fraction (P<0.001); furthermore, vortex KE was correlated negatively with energy dissipation, energy dissipation index (r=-0.44, P=0.021). Conclusion This study highlights that flow energetic indices have limited applicability as early predictors of LV progressive dysfunction, whereas vortex KE could be an alternative to LV performance.

Item Type: Article
Funders: University of Malaya Research Grant (RP028A/B/C-14HTM)
Uncontrolled Keywords: dissipation; flow; fluctuation; infarct; kinetic energy; vortex
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 11 Sep 2019 03:18
Last Modified: 11 Sep 2019 03:18
URI: http://eprints.um.edu.my/id/eprint/22285

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