Thraatchathi chooranam, protects cardiomyocytes against oxidative stress

Ganapathy, Ramakrishnan and Mani, Sugumar and Raghavendran, Hanumanth Rao Balaji and Kamarul, Tunku and Ray, Bipul and Bhat, Abid and Chidambaram, Saravana Babu (2018) Thraatchathi chooranam, protects cardiomyocytes against oxidative stress. Frontiers in Bioscience, Elite, 10 (3). pp. 437-448. ISSN 1945-0494,

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Thraatchathi Chooranam (TC), is a polyphenol-rich Indian traditional medicine. Present study was undertaken to investigate the effects of TC against H2O2 induced oxidative stress and apoptotic damage in H9C2 cardiomyocytes. Cell viability assay indicated relative safety (IC50= 488.10±12.04 mg/ml) of TC. Pretreatment of cells with TC upregulated antiapoptotic Bcl2, and anti-oxidants TRX1 and TRXR and downregulated Bax and HIF-α and inflammatory genes iNOS and TNF-α. Together, these findings show that TC has both anti-oxidant and anti-apoptotic properties. Further studies may be considered to identify the bioactive principle(s) and precise mechanisms of action of TC.

Item Type: Article
Funders: University of Malaya (Reference number: UM.C/625/1/HIR/MOHE/CHAN/03; account number: A000003-50001)
Uncontrolled Keywords: Thraatchathi Chooranam; Polyphenols; Cardiovascular Disease; Hydrogen peroxide; Antiapoptotic; Oxidative stress; Cytokine
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 26 Aug 2019 02:11
Last Modified: 26 Aug 2019 02:11

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