Gender differences in mortality among ST elevation myocardial infarction patients in Malaysia from 2006 to 2013

Juhan, Nurliyana and Zubairi, Yong Zulina and Zuhdi, Ahmad Syadi Mahmood and Khalid, Zarina Mohd and Ahmad, Wan Azman Wan (2018) Gender differences in mortality among ST elevation myocardial infarction patients in Malaysia from 2006 to 2013. Annals of Saudi Medicine, 38 (1). pp. 1-7. ISSN 0256-4947, DOI

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BACKGROUND: Coronary artery disease (CAD) is one of the leading causes of death in Malaysia. However, the prevalence of CAD in males is higher than in females and mortality rates are also different between the two genders. This suggest that risk factors associated with mortality between males and females are different, so we compared the clinical characteristics and outcome between male and female STEMI patients. OBJECTIVES: To identify the risk factors associated with mortality for each gender and compare differences, if any, among ST-elevation myocardial infarction (STEMI) patients. DESIGN: Retrospective analysis. SETTINGS: Hospitals across Malaysia. PATIENTS AND METHODS: We analyzed data on all STEMI patients in the National Cardiovascular Database-Acute coronary syndrome (NCVD-ACS) registry for the years 2006 to 2013 (8 years). We collected demographic and risk factor data (diabetes mellitus, hypertension, smoking status, dyslipidaemia and family history of CAD). Significant variables from the univariate analysis were further analysed by a multivariate logistic analysis to identify risk factors and compare by gender. MAIN OUTCOME MEASURES: Differential risk factors for each gender. RESULTS: For the 19484 patients included in the analysis, the mortality rate over the 8 years was significantly higher in females (15.4%) than males (7.5%) (P < .001). The univariate analysis showed that the majority of male patients < 65 years while females were >=65 years. The most prevalent risk factors for male patients were smoking (79.3%), followed by hypertension (54.9%) and diabetes mellitus (40.4%), while the most prevalent risk factors for female patients were hypertension (76.8%), followed by diabetes mellitus (60%) and dyslipidaemia (38.1%). The final model for male STEMI patients had seven significant variables: Killip class, age group, hypertension, renal disease, percutaneous coronary intervention and family history of CVD. For female STEMI patients, the significant variables were renal disease, smoking status, Killip class and age group. CONCLUSION: Gender differences existed in the baseline characteristics, associated risk factors, clinical presentation and outcomes among STEMI patients. For STEMI females, the rate of mortality was twice that of males. Once they reach menopausal age, when there is less protection from the estrogen hormone and there are other risk factors, menopausal females are at increased risk for STEMI. LIMITATION: Retrospective registry data with inter-hospital variation.

Item Type: Article
Uncontrolled Keywords: Age Factors; Aged; Demography; Female; Hospital Mortality; Humans; Malaysia; Male; Menopause; Middle Aged; Percutaneous Coronary Intervention; Registries; Retrospective Studies; Risk Factors; Sex Factors; ST Elevation Myocardial Infarction
Subjects: Q Science > Q Science (General)
R Medicine
Divisions: Centre for Foundation Studies in Science > Mathematics Division
Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 31 Jul 2019 04:25
Last Modified: 31 Jul 2019 04:25

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