Determinants of quality of life and psychological status in adults with psoriasis

Kwan, Zhenli and Bong, Yii Bonn and Tan, Leng Leng and Lim, Shu Xian and Yong, Adrian Sze Wai and Ch'ng, Chin Chwen and Tan, Maw Pin and Ismail, Rokiah (2018) Determinants of quality of life and psychological status in adults with psoriasis. Archives of Dermatological Research, 310 (5). pp. 443-451. ISSN 0340-3696, DOI

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We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Quality of life and psychological symptoms were measured using the Dermatology Life Quality Index (DLQI) and the Depression Anxiety Stress Scale (DASS), respectively. One hundred individuals were recruited. Unadjusted analysis revealed that head involvement was associated with depression [odds ratio (OR) 8.509; 95% confidence interval (CI) 1.077–67.231] and anxiety (OR 6.46; 95% CI 1.401–29.858). Severe disease was associated with a poorer quality of life compared to mild disease (OR 3.750; 95% CI 1.330–10.577). Younger age was associated with an increased risk of depression [mean difference (MD) − 8.640; 95% CI − 16.390 to − 0.890], anxiety (MD − 11.553; 95% CI − 18.478 to− 4.628), stress (MD − 11.440; 95% CI − 19.252 to − 3.628) and severely impaired quality of life (MD − 12.338; 95% CI − 19.548 to − 5.127). Following adjustments for age and disease severity, anxiety, stress and depression remained associated with severely impaired quality of life.

Item Type: Article
Uncontrolled Keywords: Anxiety; Depression; Psoriasis; Psychological stress; Quality of life
Subjects: R Medicine
Divisions: Faculty of Medicine
Deputy Vice Chancellor (Research & Innovation) Office > Institute of Research Management and Services
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Jun 2019 08:17
Last Modified: 27 Jun 2019 08:17

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