Quantitative assessment of wound healing using high-frequency ultrasound image analysis

Mohafez, Hamidreza and Ahmad, Siti Anom and Hadizadeh, Maryam and Moghimi, Sanar and Roohi, Sharifah Ahmad and Marhaban, Mohammad Hamiruce and Saripan, M. Iqbal and Rampal, Sanjiv (2017) Quantitative assessment of wound healing using high-frequency ultrasound image analysis. Skin Research and Technology, 24 (1). pp. 45-53. ISSN 0909-752X, DOI https://doi.org/10.1111/srt.12388.

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Official URL: https://doi.org/10.1111/srt.12388


Purpose: We aimed to develop a method for quantitative assessment of wound healing in ulcerated diabetic feet. Methods: High-frequency ultrasound (HFU) images of 30 wounds were acquired in a controlled environment on post-debridement days 7, 14, 21, and 28. Meaningful features portraying changes in structure and intensity of echoes during healing were extracted from the images, their relevance and discriminatory power being verified by analysis of variance. Relative analysis of tissue healing was conducted by developing a features-based healing function, optimised using the pattern-search method. Its performance was investigated through leave-one-out cross-validation technique and reconfirmed using principal component analysis. Results: The constructed healing function could depict tissue changes during healing with 87.8% accuracy. The first principal component derived from the extracted features demonstrated similar pattern to the constructed healing function, accounting for 86.3% of the data variance. Conclusion: The developed wound analysis technique could be a viable tool in quantitative assessment of diabetic foot ulcers during healing.

Item Type: Article
Funders: Research University Grant Scheme (RUGS#9377800) obtained from Universiti Putra Malaysia
Uncontrolled Keywords: dermatologic sonography; diabetic foot ulcer; healing function; high-frequency ultrasound imaging; image processing; pattern search optimisation; wound healing assessment
Subjects: R Medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Sports and Exercise Science (formerly known as Centre for Sports & Exercise Sciences)
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 21 May 2019 07:00
Last Modified: 21 May 2019 07:00
URI: http://eprints.um.edu.my/id/eprint/21273

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