1,3-oxazepine compounds derived from azomethine: Synthesis, characterization and antibacterial evaluation

Mohammed, Issam Ahmed and Ahmed, Mahmood and Ikram, Rabia and Qadir, Muhammad Abdul and Hussain, Riaz (2018) 1,3-oxazepine compounds derived from azomethine: Synthesis, characterization and antibacterial evaluation. Latin American Journal of Pharmacy, 37 (3). pp. 540-546. ISSN 0326-2383,

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Official URL: http://www.latamjpharm.org/resumenes/37/3/LAJOP_37...


Two azomethines, namely 2-methoxy-4-phenyliminomethyl-phenol (1) and 4-[(2,4-dinitro-phenyl)-hydrazonomethyl]-2-methoxy-phenol (2) were prepared between the reaction of vanillin with aniline and 2,4-dinitrophenylhydrazine, respectively. Subsequently, these two azomethines were reacted via direct cyclic addition with maleic anhydride, phthalic anhydride and succinic anhydride, respectively, yielded a series of new 1,3-oxazepines (3-8). All the synthesized compounds were characterized on the basis of FT-IR, NMR, MS and elemental analysis (CHN). Disk diffusion and 96-well plate assay methods were employed for zone of inhibition and minimum inhibitory concentration determination respectively to investigate the antibacterial activities. Our studies showed that compound 5 showed promising antibacterial activities with zone of inhibition 24.7 mm against S. aureus, AI value 77.2 % compare to standard ciprofloxacin and MIC was 31.25 μg/mL.

Item Type: Article
Uncontrolled Keywords: Antibacterial activities; Azomethines; MIC
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 15 May 2019 08:52
Last Modified: 15 May 2019 08:52
URI: http://eprints.um.edu.my/id/eprint/21247

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