New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents

Mohd Sofyan, Nur Rahimah Fitrah and Nordin, Fariza Juliana and Mohd Abd Razak, Mohd Ridzuan and Abdul Halim, Syahrina Nur 'Ain and Mohd Khir, Nur Adila Fatin and Muhammad, Amirrudin and Rajab, Nor Fadilah and Sarip, Rozie (2018) New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents. Journal of Chemistry, 2018. pp. 1-10. ISSN 2090-9063, DOI

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Five silver(I) complexes containing a mixed ligand system of phosphine and thiazolidine were successfully synthesized. The structural information of the complexes was assembled using various spectroscopic techniques such as CHN elemental analysis, Fourier transformed infrared (FTIR), 1 H, 13 C, and 31 P{ 1 H} NMR spectroscopy, and thermogravimetric analysis (TGA). A bidentate phosphine ligand acted as a chelating agent which bond to the silver in 1: 2 molar ratios. Meanwhile, thiazolidine was attached to the silver in a 1: 1 molar ratio. The antiplasmodial properties of all synthesized complexes were investigated on chloroquine-resistant P. falciparum parasite via HRP2 assays and cytotoxicity tests on Vero cells. Of all the synthesized complexes, complex 2 showed the highest SI value (more than 12.4) followed by complex 5 (6.6). The potent properties of compounds 2 and 5 were also noted in the in vitro antiproliferative assays involving MDA-MB-231 and MCF-7 breast cancer cell lines as well as HT-29 colon cancer cell line. Complex 2 was selective for MDA-MB-231 cells (GI 50 = 1.9 ± 0.3 μM), while complex 5 acted predominantly on breast carcinoma cells (GI 50 MDA-MB-231 = 4.7 ± 1.1 μM; MCF-7 = 2.9 ± 0.9 μM) instead of colon carcinoma (HT-29) cells (GI 50 = 15.1 ± 1.9 μM).

Item Type: Article
Funders: Fundamental Research Grant Scheme (FRGS) (Grant no. FP047-2014A), University of Malaya IPPP Grant (Grant no. PG001-2015A)
Uncontrolled Keywords: Silver complexes; thiazolidine; phosphine ligands; antimalarial; anticancer; agents
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 May 2019 08:51
Last Modified: 14 May 2019 08:51

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