Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

Nor Azman, Nadiah Syafiqah and Hossan, Md Shahadat and Nissapatorn, Veeranoot and Uthaipibull, Chairat and Prommana, Parichat and Jin, Khoo Teng and Rahmatullah, Mohammed and Mahboob, Tooba and Samudi, Chandramathi and Jindal, Hassan Mahmood and Hazra, Banasri and Mohd Abd Razak, Mohd Ridzuan and Prajapati, Vijay Kumar and Pandey, Rajan Kumar and Aminudin, Norhaniza and Shaari, Khozirah and Ismail, Nor Hadiani and Butler, Mark S. and Zarubaev, Vladimir V. and Wiart, Christophe (2018) Anti-infective activities of 11 plants species used in traditional medicine in Malaysia. Experimental Parasitology, 194. pp. 67-78. ISSN 0014-4894, DOI

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Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against MRC-5 cells and Leishmania donovani by MTT, and chloroquine-resistant Plasmodium falciparum K1 strain by Histidine-Rich Protein II ELISA assays. None of the extract tested was cytotoxic to MRC-5 cells. Extracts of Uvaria grandiflora, Chilocarpus costatus, Tabernaemontana peduncularis, and Leuconotis eugenifolius had good activities against L. donovani with IC50 < 50 μg/mL. Extracts of U. grandiflora, C. costatus, T. peduncularis, L. eugenifolius, A. subulatum, and C. aeruginosa had good activities against P. falciparum K1 with IC50 < 10 μg/mL. Pinoresinol isolated from C. costatus was inactive against L. donovani and P. falciparum. C. costatus extract and pinoresinol increased the sensitivity of Staphylococcus epidermidis to cefotaxime. Pinoresinol demonstrated moderate activity against influenza virus (IC50 = 30.4 ± 11 μg/mL) and was active against Coxsackie virus B3 (IC50 = 7.1 ± 3.0 μg/mL). β-Amyrin from L. eugenifolius inhibited L. donovani with IC50 value of 15.4 ± 0.01 μM. Furanodienone from C. aeruginosa inhibited L. donovani and P. falciparum K1 with IC50 value of 39.5 ± 0.2 and 17.0 ± 0.05 μM, respectively. Furanodienone also inhibited the replication of influenza and Coxsackie virus B3 with IC50 value of 4.0 ± 0.5 and 7.2 ± 1.4 μg/mL (Ribavirin: IC50: 15.6 ± 2.0 μg/mL), respectively. Our study provides evidence that medicinal plants in Malaysia have potentials as a source of chemotypes for the development of anti-infective leads.

Item Type: Article
Funders: Ministry of Higher Education Malaysia (Fundamental Research Grant Scheme FRGS/1/2014/SG01/UNIM/02/1), University of Malaya Research Grants UMRG 544/14HTM and UMRG 362-15AFR, Thailand National Science and Technology Development Agency ( P1450883 ), National Center for Genetic Engineering and Biotechnology and Thailand Research Fund ( RSA5880064 )
Uncontrolled Keywords: Antimalarial; Antileishmanial; Antiviral; Antibacterial; Medicinal plants; Natural products; Malaysia
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
R Medicine
Divisions: Faculty of Medicine
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 03 May 2019 07:44
Last Modified: 03 May 2019 07:44

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