Polyisoprenylated Acylphloroglucinols from Garcinia nervosa

Nugroho, Alfarius Eko and Nakamura, Hitomi and Inoue, Daisuke and Hirasawa, Yusuke and Wong, Chin Piow and Kaneda, Toshio and A. Hadi, A. Hamid and Morita, Hiroshi (2018) Polyisoprenylated Acylphloroglucinols from Garcinia nervosa. Natural Product Communications, 13 (3). pp. 367-369. ISSN 1934-578X, DOI https://doi.org/10.1177/1934578X1801300324.

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Official URL: https://doi.org/10.1177/1934578X1801300324


Two new polyisoprenylated acylphloroglucinols, 7-epi-isoxanthochymol and 7-epi-cycloxanthochymol (1 – 2), were isolated from the barks of Garcinia nervosa together with their 7-epimers isoxanthochymol (3) and cycloxanthochymol (4). Their structures were determined on the basis of NMR spectroscopic data. The cytotoxic activity of the isolated compounds against HL-60, MCF-7 (human breast adenocarcinoma), A549 (human lung adenocarcinoma) and HepG2 (human hepatocellular carcinoma) cells were evaluated, and all compounds showed cytotoxic activity against all cell lines.

Item Type: Article
Funders: Japan Society for the Promotion of Science: Grants in-Aid for Scientific Research
Uncontrolled Keywords: Garcinia nervosa; Clusiaceae; Acylphloroglucinols; Cytotoxicity
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Apr 2019 01:53
Last Modified: 02 Sep 2021 04:25
URI: http://eprints.um.edu.my/id/eprint/21096

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