Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives

Phong, Win Nee and Show, Pau Loke and Ling, Tau Chuan and Juan, Joon Ching and Ng, Eng Poh and Chang, Jo-Shu (2018) Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives. Algal Research, 31. pp. 506-516. ISSN 2211-9264, DOI

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Bio-functional proteins from microalgae have numerous biological properties with health-promoting effects. However, efficient harnessing of bio-functional proteins from microalgae is still in its infancy. One of the major obstacles that hinder the mass production of bio-functional proteins is the presence of resistant cell wall that diminishes the liberation of cell contents. As the bio-functional proteins are very sensitive to denaturation, selecting a mild disruption method to rupture the cell wall, while preserving their bioactivity and functionality, is of vital importance in downstream processing. To ensure the future development of efficient mild disruption methods for maximum recovery of bio-functional proteins from microalgae, this review provides useful information on various mild disruption approaches, current status, potential technologies that are still under development, as well as their advantages and constraints. In particular, those potential technologies that require further attention in the future (namely, explosive decompression, microfluidization, pulsed arc technology and cationic polymer coated membranes) are also discussed in this review.

Item Type: Article
Funders: SATU Joint Research Scheme (RU018L-2016, RU018O-2016 and RU018C-2016) from University of Malaya (PG250-2015B), Malaysia's Fundamental Research Grant Scheme (FRGS/1/2015/SG05/UNIM/03/1), Prototype Research Grant Scheme (PRGS/2/2015/SG05/UNIM/03/1), Malaysia's Ministry of Science, Technology, Innovation (MOSTI 02-02-12-SF0256), Taiwan's Ministry of Science and Technology (106-3113-E-006-011, 106-3113-E-006-004CC2, and 103-2221-E-006-190-MY3), Taiwan's Ministry of Education on Top University Grants
Uncontrolled Keywords: Microalgae; Bio-functional proteins; Cell wall; Mild cell disruption
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Apr 2019 02:06
Last Modified: 16 Jun 2020 01:54

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