Comparative efficacy of hemorrhage control of a novel mesoporous bioactive glass versus two commercial hemostats

Pourshahrestani, Sara and Kadri, Nahrizul Adib and Zeimaran, Ehsan and Gargiulo, Nicola and Samuel, Shani and Naveen, Sangeetha Vasudevaraj and Hasikin, Khairunnisa and Kamarul, Tunku and Towler, Mark Robert (2018) Comparative efficacy of hemorrhage control of a novel mesoporous bioactive glass versus two commercial hemostats. Biomedical Materials, 13 (2). 025020. ISSN 1748-6041, DOI

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Mesoporous bioactive glass containing 1% Ga 2 O 3 (1%Ga-MBG) is attractive for hemorrhage control because of its surface chemistry which can promote blood-clotting. The present study compares this proprietary inorganic coagulation accelerator with two commercial hemostats, Celox™ (CX) and QuikClot Advanced Clotting Sponge Plus™ (ACS + ). The results indicate that the number of adherent platelets were higher on the 1%Ga-MBG and CX surfaces than ACS + whereas a greater contact activation was seen on 1%Ga-MBG and ACS + surfaces than CX. 1%Ga-MBG not only resulted in larger platelet aggregates and more extensive platelet pseudopodia compared to CX and ACS + but also significantly accelerated the intrinsic pathways of the clotting cascade. In vitro thrombin generation assays also showed that CX and ACS + induced low levels of thrombin formation while 1%Ga-MBG had significantly higher values. 1%Ga-MBG formed a larger red blood cell aggregate than both CX and ACS + . Direct exposure of 1%Ga-MBG to fibroblast cells increased cell viability after 3 days relative to CX and ACS + , inferring excellent cytocompatibility. The results of this study promote 1%Ga-MBG as a promising hemostat compared to the commercially available products as it possesses essential factors required for coagulation activation.

Item Type: Article
Funders: Ministry of Higher Education (MOHE), Government of Malaysia, under the High Impact Research (UM.C/625/1/HIR/MoE/ ENG/58), University of Malaya Research Grants scheme (UMRG, RP038A-15HTM), Post-graduate Research Grant (PPP: PG077-2015B)
Uncontrolled Keywords: Celox™; hemostasis; hemostatic activity; mesoporous bioactive glass; platelet activation; quikclot advanced clotting sponge plus™
Subjects: R Medicine
Divisions: Faculty of Engineering
Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Apr 2019 07:45
Last Modified: 18 Apr 2019 07:45

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