Influence of a nonionic surfactant on curcumin delivery of nanocellulose reinforced chitosan hydrogel

Sampath Udeni Gunathilake, Thennakoon M. and Ching, Yern Chee and Chuah, Cheng Hock and Illias, Hazlee Azil and Ching, Kuan Yong and Ramesh, Singh and Nai-Shang, Liou (2018) Influence of a nonionic surfactant on curcumin delivery of nanocellulose reinforced chitosan hydrogel. International Journal of Biological Macromolecules, 118 (Pt.A). pp. 1055-1064. ISSN 0141-8130, DOI

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Nanocellulose reinforced chitosan hydrogel was synthesized using chemical crosslinking method for the delivery of curcumin which is a poorly water-soluble drug. Curcumin extracted from the dried rhizomes of Curcuma longa was incorporated to the hydrogel via in situ loading method. A nonionic surfactant (Tween 20) was incorporated into the hydrogel to improve the solubility of curcumin. After the gas foaming process, hydrogel showed large interconnected pore structures. The release studies in gastric medium showed that the cumulative release of curcumin increased from 0.21% ± 0.02% to 54.85% ± 0.77% with the increasing of Tween 20 concentration from 0% to 30% (w/v) after 7.5 h. However, the entrapment efficiency percentage decreased with the addition of Tween 20. The gas foamed hydrogel showed higher initial burst release within the first 120 min compared to hydrogel formed at atmospheric condition. The solubility of curcumin would increase to 3.014 ± 0.041 mg/mL when the Tween 20 concentration increased to 3.2% (w/v) in simulated gastric medium. UV–visible spectra revealed that the drug retained its chemical activity after in vitro release. From these findings, it is believed that the nonionic surfactant incorporated chitosan/nanocellulose hydrogel can provide a platform to overcome current problems associated with curcumin delivery.

Item Type: Article
Funders: Ministry of Education Malaysia : FP053-2015A and PR005-2017A, University Malaya research grant: PG160-2016A , RU005D-2016 , and ST012-2017 and RU018I-2016, International Funding AUA Scholars IF025-2018
Uncontrolled Keywords: Nanocellulose; Chitosan; Hydrogel; Curcumin; Tween 20
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
T Technology > TJ Mechanical engineering and machinery
T Technology > TK Electrical engineering. Electronics Nuclear engineering
T Technology > TP Chemical technology
Divisions: Faculty of Engineering
Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 22 Mar 2019 04:18
Last Modified: 22 Mar 2019 04:18

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