Myofibroblastoma of the breast

Sanmugasiva, Vithya Visalatchi and Ramli, Marlina Tanty and Fadzli, Farhana and Kaur, Shaleen and Abdul Rahman, Nazarina and Rahmat, Kartini (2018) Myofibroblastoma of the breast. Malaysian Journal of Pathology, 40 (3). pp. 349-353. ISSN 0126-8635,

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Introduction: Myofibroblastoma is a rare benign mesenchymal tumour arising from the stromal elements of the breast tissue. Histopathological variants such as classic, cellular, collagenous / fibrous, lipomatous, infiltrative, myxoid and epithelioid have been identified. Most myofibroblastomas are immunoreactive for CD34, actin, CD10 and desmin, usually express oestrogen receptor (ER), progesterone receptor (PR) and variably express androgen receptor (AR). Case report: We report a case of myofibroblastoma in an octogenarian male presenting with painless solitary breast lump. Mammography (digital tomosynthesis) and ultrasound showed a well-circumscribed hyperdense mass and hypoechoic, solid, oval mass with peripheral vascularity respectively. Patient underwent wide local excision. Discussion: Diverse characteristics of myofibroblastoma on imaging necessitates histopathological analysis for an accurate diagnosis. Myofibroblastoma are often confused with fibroadenomas due to the benign imaging characteristics and with malignant neoplasia due to their wide morphological spectrum. Surgical excision is considered curative.

Item Type: Article
Uncontrolled Keywords: Myofibroblastoma; breast; mammography; ultrasound; spindle cell tumour
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 20 Mar 2019 06:34
Last Modified: 20 Mar 2019 06:34

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