Green synthesis of anisotropic zinc oxide nanoparticles with antibacterial and cytofriendly properties

Saravanan, Muthupandian and Gopinath, Venkatraman and Chaurasia, Mukesh Kumar and Syed, Asad and Ameen, Fuad and Purushothaman, Natarajan (2018) Green synthesis of anisotropic zinc oxide nanoparticles with antibacterial and cytofriendly properties. Microbial Pathogenesis, 115. pp. 57-63. ISSN 0882-4010, DOI

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Zinc oxide nanoparticles (ZnONPs) exhibit abundant biomedical applications. Anisotropic ZnONPs with a defined shape and size were synthesized using Bacillus megaterium (NCIM 2326) cell free extract as a bio-reductant. The study investigated the multidimensional effect of ZnONPs on Helicobacter pylori strains and assessed its biosafety in normal human mesenchymal stem cells (hMSc). The highly stable ZnONPs were produced using B. megaterium and Zinc nitrate as a precursor. The phase of ZnONPs formation and structural characterization were performed by UV- visible (UV-Vis), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Field Emission Scanning electron microscopy (FESEM) analysis. Furthermore, the ZnONPs exhibited higher biocompatibility against human mesenchymal stem cells (hMSC) and proved to be potentially safe in mammalian cells. Corroborating the current investigation, we described the anti-H. Pylori dosage of ZnONPs was safe to hMSC and could efficiently use as nano-antibiotic.

Item Type: Article
Funders: Deanship of Scientific Research at King Saud University for funding this work through research group No (RG-1438-078)
Uncontrolled Keywords: Bacillus megaterium; Nanoparticles; Antibacterial mechanism; Helicobacter pylori; Cytotoxicity
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 20 Mar 2019 03:38
Last Modified: 20 Mar 2019 03:38

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