Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways

Sok, Sophia Ping Meow and Ori, Daisuke and Nagoor, Noor Hasima and Kawai, Taro (2018) Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways. Critical Reviews in Immunology, 38 (4). pp. 279-301. ISSN 1040-8401, DOI

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The innate immune system serves as the first line of defense to protect the host from pathogen infection. As a first step, the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), such as non-self DNA derived from pathogens, and damage-associated molecular patterns (DAMPs), such as self DNA released from damaged or injured cells. Sensing of such DNAs elicits innate immune responses through the production of type I interferons (IFNs) and proinflammatory cytokines resulting from the activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB), respectively. These cytokines are key players in interlinking innate and adaptive immune responses. However, defects in DNA sensors and their signaling cascades lead to dysregulation of immune responses, autoimmune diseases, and cancer progression. Here we provide an update on DNA signaling pathways in response to pathogen infection and cell injury, and on the roles of regulators in governing the immune system and maintaining host homeostasis. We also discuss the evasion of immunosurveillance by pathogens.

Item Type: Article
Funders: Japan Ministry of Education, Culture, Sports, Science and Technology KAKENHI Challenging Research (Exploratory) 17K19559 (T. K.), Grant-in-Aid for Scientific Research (B) 17H04066 (T. K.), and Grant-in-Aid for Young Scientists (B) 17K15726 (D. O.), University of Malaya through University Malaya Research Fund Assistance (BKP) BKS055-2017
Uncontrolled Keywords: DNA sensors; cGAS-STING; Toll-like receptor; inflammasome; autoimmunity; innate immunity
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 11 Mar 2019 04:28
Last Modified: 11 Mar 2019 04:28

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