Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

Tan, Loh Teng Hern and Chan, Kok Gan and Chan, Chim Kei and Khan, Tahir Mehmood and Lee, Learn Han and Goh, Bey Hing (2018) Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil. BioMed Research International, 2018. pp. 1-13. ISSN 2314-6133, DOI

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Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Streptomyces. Strain MUM292 showed the highest 16S rRNA gene sequence similarity of 99.54% with S. griseoruber NBRC12873T. Furthermore, strain MUM292 was also characterized and showed phenotypic characteristics consistent with Streptomyces bacteria. Fermentation and extraction were performed to obtain the MUM292 extract containing the secondary metabolites of strain MUM292. The extract displayed promising antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging and also metal-chelating activities. The process of lipid peroxidation in lipid-rich product was also retarded by MUM292 extract and resulted in reduced MDA production. The potential bioactive constituents of MUM292 extract were investigated using GC-MS and preliminary detection showed the presence of pyrazine, pyrrole, cyclic dipeptides, and phenolic compound in MUM292 extract. This work demonstrates that Streptomyces MUM292 can be a potential antioxidant resource for food and pharmaceutical industries.

Item Type: Article
Funders: Monash University Malaysia ECR Grant (5140077-000-00), MOSTI eScience Fund (02-02-10-SF0215), University of Malaya for Research Grant (GA001-2016, GA002-2016, and PPP Grant no. PG133-2016A), External Industry Grants from Biotek Abadi Sdn Bhd (Vote no. GBA-808138 and GBA-808813)
Uncontrolled Keywords: Antioxidants; Biphenyl Compounds; Cell Extracts; Fermentation; Lipid Peroxidation; Phylogeny; Picrates; Soil Microbiology; Streptomyces; Wetlands
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
R Medicine
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 28 Feb 2019 05:01
Last Modified: 28 Feb 2019 05:01

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