Risk of Preeclampsia and Pregnancy Complications in Women With a History of Acute Kidney Injury

Tangren, Jessica Sheehan and Wan Md Adnan, Wan Ahmad Hafiz and Powe, Camille E. and Ecker, Jeffrey and Bramham, Kate and Hladunewich, Michelle A. and Ankers, Elizabeth and Karumanchi, S. Ananth and Thadhani, Ravi (2018) Risk of Preeclampsia and Pregnancy Complications in Women With a History of Acute Kidney Injury. Hypertension, 72 (2). pp. 451-459. ISSN 0194-911X, DOI https://doi.org/10.1161/HYPERTENSIONAHA.118.11161.

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Official URL: https://doi.org/10.1161/HYPERTENSIONAHA.118.11161


An episode of clinically recovered acute kidney injury (r-AKI) has been identified as a risk factor for future hypertension and cardiovascular disease. Our objective was to assess whether r-AKI was associated with future preeclampsia and other adverse pregnancy outcomes and to identify whether severity of AKI or time interval between AKI and pregnancy was associated with pregnancy complications. We conducted a retrospective cohort study of women who delivered infants between 1998 and 2016 at Massachusetts General Hospital. AKI was defined using the 2012 Kidney Disease Improving Global Outcomes laboratory criteria with subsequent clinical recovery (estimate glomerular filtration rate, >90 mL/min per 1.73 m2 before conception). AKI was further classified by severity (Kidney Disease Improving Global Outcomes stages 1-3) and time interval between AKI episode and the start of pregnancy. Women with r-AKI had an increased rate of preeclampsia compared with women without previous r-AKI (22% versus 9%; P<0.001). Infants of women with r-AKI were born earlier (gestational age, 38.2±3.0 versus 39.0±2.2 weeks; P<0.001) and were more likely to be small for gestational age (9% versus 5%; P=0.002). Increasing severity of r-AKI was associated with increased risk of preeclampsia for stages 2 and 3 AKI (adjusted odds ratio, 3.5; 95% confidence interval, 2.1-5.7 and adjusted odds ratio, 6.5; 95% confidence interval, 3.5-12.0, respectively), but not for stage 1 (adjusted odds ratio, 1.7; 95% confidence interval, 0.9-3.2). A history of AKI before pregnancy, despite apparent full recovery, was associated with increased risk of pregnancy complications. Severity and timing of the AKI episode modified the risk.

Item Type: Article
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK; K23DK113218-01), Robert Wood Johnson Foundation’s Harold Amos Medical Faculty Development Program (74256)
Uncontrolled Keywords: Acute kidney injury; Epidemiology; Hypertension; Preeclampsia; Pregnancy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Feb 2019 00:53
Last Modified: 27 Feb 2019 00:53
URI: http://eprints.um.edu.my/id/eprint/20508

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