Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia

Tajudin, Muhammad Abdul Basit Ahmad and Khan, Md Firoz and Mahiyuddin, Wan Rozita Wan and Hod, Rozita and Latif, Mohd Talib and Hamid, Ahmad Hazuwan and Rahman, Sufian Abd and Sahani, Mazrura (2019) Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia. Ecotoxicology and Environmental Safety, 171. pp. 290-300. ISSN 0147-6513, DOI https://doi.org/10.1016/j.ecoenv.2018.12.057.

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Official URL: https://doi.org/10.1016/j.ecoenv.2018.12.057


Rapid urbanisation in Malaysian cities poses risks to the health of residents. This study aims to estimate the relative risk (RR) of major air pollutants on cardiovascular and respiratory hospitalisations in Kuala Lumpur. Daily hospitalisations due to cardiovascular and respiratory diseases from 2010 to 2014 were obtained from the Hospital Canselor Tuanku Muhriz (HCTM). The trace gases, PM10 and weather variables were obtained from the Department of Environment (DOE) Malaysia in consistent with the hospitalisation data. The RR was estimated using a Generalised Additive Model (GAM) based on Poisson regression. A “lag” concept was used where the analysis was segregated into risks of immediate exposure (lag 0) until exposure after 5 days (lag 5). The results showed that the gases could pose significant risks towards cardiovascular and respiratory hospitalisations. However, the RR value of PM10 was not significant in this study. Immediate effects on cardiovascular hospitalisations were observed for NO2 and O3 but no immediate effect was found on respiratory hospitalisations. Delayed effects on cardiovascular and respiratory hospitalisations were found with SO2 and NO2. The highest RR value was observed at lag 4 for respiratory admissions with SO2 (RR = 1.123, 95% CI = 1.045–1.207), followed by NO2 at lag 5 for cardiovascular admissions (RR = 1.025, 95% CI = 1.005–1.046). For the multi-pollutant model, NO2 at lag 5 showed the highest risks towards cardiovascular hospitalisations after controlling for O3 8 h mean lag 1 (RR = 1.026, 95% CI = 1.006–1.047), while SO2 at lag 4 showed highest risks towards respiratory hospitalisations after controlling for NO2 lag 3 (RR = 1.132, 95% CI = 1.053–1.216). This study indicated that exposure to trace gases in Kuala Lumpur could lead to both immediate and delayed effects on cardiovascular and respiratory hospitalisations.

Item Type: Article
Funders: Universiti Kebangsaan Malaysia: Research University Grants, Malaysia (AP-2015-010 and DIP-2014-015), Ministry of Education for the Fundamental Research Grant, Malaysia (FRGS/2/2014/SG03/UKM/03/2)
Uncontrolled Keywords: Urban air pollution; Trace gases; Cardiovascular diseases; Respiratory diseases; Relative risks
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Jan 2019 08:38
Last Modified: 14 Jan 2019 08:38
URI: http://eprints.um.edu.my/id/eprint/19987

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